منابع مشابه
Minipig Translational Research Models
Miniature swine have been utilized as translational research models with outcomes in high concordance with humans in a variety of systems. Much of the data justifying the minipig models has been published in books and review manuscripts.1-16 Summary publications of some of the major models have also been published online (http://www.sinclairresearch.com/Literature/Literature. aspx). Major syste...
متن کاملSpontaneous Object Recognition in the Göttingen Minipig
Göttingen minipigs were tested in an object recognition procedure based on spontaneous exploration. Eight pigs were exposed to two similar objects in a sample trial and after a one-hour delay exposed to two objects, one familiar and one novel, in a test trial. The pigs explored the novel object significantly more than the familiar object in the test trial (p<0.05), thereby showing recognition o...
متن کاملNucleotide profiles in normal minipig arterial tissue.
The purpose of this study was to characterize the nucleotide profiles of a normal porcine elastic and muscular artery. Tissue samples (50 to 150 mg) were excised from the descending thoracic aorta and from the femoral artery of 14 normocholesterolemic, anesthetized minipigs. In three animals, transmural myocardial samples were also obtained. Nucleotide and nucleoside concentrations were analyze...
متن کاملDistribution of CGRP in the minipig brainstem.
For the first time, an in-depth study has been made of the distribution of fibers and cell bodies containing calcitonin gene-related peptide (CGRP) in the minipig brainstem using an indirect immunoperoxidase technique. The animals studied were not treated with colchicine. Cell bodies containing CGRP were found in 20 nuclei/regions of the brainstem. These perikarya were located in somatomotor, b...
متن کاملThe Göttingen minipig in translational neuroscience
introduction Animal models are essential in the development of novel treatment paradigms for most diseases, and for decades rodent models of various diseases have been imperative. The translation of results and treatment options from these small animals to humans often requires the use of a large animal as an intermediate step. Nonhuman primates have been used for this purpose, as this species ...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2010
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm1210-1349a